Read the previous comments.  If it hasn't been explored yet, I would suggest that your grandfather get a coronary calcium C-T scan and a calcium score for arteriosclerosis !  Why ?  Because there is a differnence between arteriosclerosis ( Calcium 'Hardening of the Arteries' ), and athersclerosis ( Cholesterol & triglycerides ) !  Statins are specificallyappplied to the latter for cholesterol, triglyceride, and some inflammation reduction.  Some Doctors mistakenly use statins too for the calcium buildup problem !  If cholesterol is high and requires reduction, the said effects of the statins that dis-agree with ones system are a fact - One must discover through trial-and-error which statin(s) work best for your system ... but stains were never designed to combat arteriosclerosis ( Calcium hardening of the arteries ) --  Chelation is the recommended appication - of which the previously cited intra-venous EDTA has been applied, but 'Doctor's office intravenous' is not the sole solution ...

The abundance of calcium in one's system is largely due to the fact that calcium requires magnesium ( from green leafy vegetables, strawberries, etc ) to be digested and assimilated in your system ( That is why you will see the vitamin combination Ca/ Mg for sale as a single vitamin unit ).  A primary chelation agent for the dissolution of calcified blood vessels, is powdered magnesium - such as in the the marketed powder product called "Calm" ( Magnesium is a vaso-dialator, therefore it is used a natuaral sleep-inducing agent at bedtime for those with anxiety ).  One puts 1 or 2 teaspoons of this powder in a glass of warm water and drink it at home.  Chelation is thereafter underway.

There may be a dietary reason an individual doesn't get enough magnesium in their diet ( not enough magnesium-rich foods - such as the deep color vegetables - think of the ingestion of a pizza with all of its cheese, with no green vegetables or magnesium inputted to aid in the breakdown of that calcium load ... ); or possibly there is an assimilation problem ( In other words the person could eat plenty of magnesium-rich food, yet absorption for assimilation does not occur.  Some patients, such as those with genetic hyper - aldosteronism in cause, which drives classic genetic Type I Essential or Primary Hypertension ( As compared with the Type II Causal or Resultant Hypertension - this one being reversible ), are subject to the system attempting to relieve the system of its excess aldosterone ( adrenalin booster ) by deliberately rinsing the hormone from the system - but inadvertantly carrying electrolytes like potassium and magnesium with it in the urine flow - which further enhances the hypertension - very common problem ... ), the patient would need to supplement with these minerals for the rest of their life.

A Naturopathic doctor might have better answers for you if a standard Doctor or internist comes up short in explanation on chelation and nutritional applications.  Read these important books on the issue of the statins, their mis-applications, the statistics, and the recommended solutions as to pain elimination and health recovery -- I believe you will be surprised in what these men have to convey:

 Hidden Causes of Heart Attack and Stroke: Inflammation, Cardiology's New Frontier, ( Barnes & Noble Bookstore No. 0972495908 );  
 Miracle Stem Cell Heart Repair: For Heart Attack, Heart Failure and Bypass Patients, ( Barnes & Noble No. 1599750546 ) both by author Christian Wilde.

Also:  Calcification: The Aging Factor, how to Defuse the Calcium Bomb, ( Barnes & Noble No. 184728633X); Author Mark Mayer .

 I've experienced this issue myself.  Best of luck;  Hope these materials help.         S.